Age-related macular degeneration (AMD) is a painless eye disease causing loss of central vision that is most common in seniors. This condition severely impacts the quality of life, which limits daily activities such as reading and recognizing faces.
There is no absolute cure for AMD. Recently, interest in the potential of cannabis to protect against the condition has grown. Many patients and researchers are searching for new solutions. Their search for “weed dispensary near me” might end at https://www.grasslife.ca/. Read on to learn more.
Key Takeaways:
- Cannabinoids can protect retinal cells from oxidative stress and other damage, which are the factors in the development of AMD.
- Retinal pigment epithelial cells contain CB1 & CB2 receptors. Cannabinoids may protect the retina.
- Both Sativa and Indica strains serve as ideal options as they contain cannabinoids that activate CB1 and CB2 receptors.
What is Age-Related Macular Degeneration?
Age-related macular degeneration (AMD) is a known progressive eye condition that affects the “macula,” which is the main part of the retina that regulates sharp and detailed vision. Causes may include aging, genetics, plaque build-up, high glycemic foods, high blood pressure, smoking, and oxidative stress.
Symptoms include:
- Sudden loss of visual accuracy
- Blurred vision
- Loss of central vision
Two types of AMD:
| Type | Description | Treatment |
| Dry | Thinning of the macula and accumulation of drusen (tiny yellow or white deposits) under the retina. | No treatment, but vision aids can help manage daily activities. |
| Wet | More severe form involving abnormal blood vessel growth under the retina, which leads to leakage and damage. | Regular eye injections and sometimes photodynamic therapy (PDT) are needed to prevent vision from worsening. |
(PDT) are needed to prevent vision from worsening.
With limited remedies, patients and researchers seek new treatments. Recent news suggests weed may be a good alternative.
What Experts Found
Cannabinoid receptors are present in nerve cells, and the endocannabinoid system may be therapeutic for neurodegenerative diseases. A 2009 laboratory test in Shanghai confirmed that human retinal pigment epithelial cells have CB1 and CB2 receptors. Cannabinoids can protect these cells from oxidative damage, a possible cause of the condition.
Cannabinoid receptors maintain homeostasis within the body, including the eyes.
- CB1 Receptors. Predominantly seen in the central nervous system, including the retina.
- CB2 Receptors. Found in the immune system and retinal cells.
Key Findings
Cannabinoid receptors are potentially therapeutic agents in neurodegenerative disorders. The study investigates the presence and role of CB1 and CB2 and the enzyme fatty acid amide hydrolase (FAAH) in one’s retinal pigment epithelial (RPE) cells related to AMD.
Methods
- Primary human RPE cells and ARPE-19 cell lines were exposed to H2O2 for 24 hours to induce oxidative damage.
- Real-time RT-PCR, immunofluorescent staining, and western blotting were used to examine the expression of CB1, CB2, and FAAH.
- Cell viability and reactive oxygen species (ROS) were measured using MTT and DCF assays.
- PI3K/Akt and ERK1/2 signalling pathways were analyzed via western blot.
Results
Evidence shows that oxidative stress affects RPE cells in AMD . Testing with RT-PCR and western blot techniques revealed that oxidative stress increases the expression of CB1 and CB2 receptors and decreases FAAH expression. This matches earlier findings that endocannabinoids rise in ARMD-affected retinas, which suggests that cannabinoid receptors might be potential targets for ARMD treatment.
Further tests revealed that a CB2 receptor agonist significantly protected RPE cells from oxidative stress, while a CB1 agonist did not. This indicates that the effects are specific to the type of cell and condition.
In conclusion, the study shows that oxidative stress alters CB1, CB2, and FAAH expression in RPE cells. This suggests a connection between endocannabinoid balance and the onset of ARMD, which highlights cannabinoid receptor manipulation as a potential treatment approach for ARMD.
Popular Weed Strains to Explore
When selecting cannabis products, understanding the difference between Sativas, Indicas, and hybrids is important. Sativas are uplifting and energizing, ideal for daytime use. Indicas are relaxing and sedative, perfect for evening use. Hybrids offer a balanced mix of both.
The best options you can try from a weed dispensary near me:
| Product | Strain Type | Flavours | THC (%) | CBD (%) | Effects |
| Bubba Kush | Indica | Vanilla, Apple | 22 | 0.6 | Heavy tranquillizing effects; powerful relaxation; dreamy euphoria; stress relief and happy moods. |
| Sour Tangie | Sativa | Citrus, Diesel | 21 | 0.4 | Creative and elevating buzz; strong citrus overtones |
| Jealousy | Hybrid (Balanced) | Diesel, Earthy | 24 | 0.2 | Mental relaxation, and physical energy, ideal for experienced users, balancing effects. |
Do Patients Have Other Options Aside From Strains?
- Edibles. Cannabis-infused foods or drinks with longer-lasting effects. A discreet consumption method and convenient for patients who prefer not to inhale cannabis.
- Tinctures. Taken sublingually or added to food and drinks. Offer a quick onset of effects and precise dosing.
- Capsules and Pills. A pre-measured dose of cannabis with a precise and long-lasting relief from symptoms. Discreet, convenient, and suitable for patients seeking sustained symptom management.
Keep Your Eyes on the Prize
Emerging research supports the potential of cannabinoids in protecting against AMD. By activating CB1 and CB2 receptors in retinal cells, cannabinoids can reduce oxidative stress and inflammation, which are major contributors to the condition’s progression.
Choose the right cannabis strains to maximize the therapeutic effects of cannabinoids. As research advances, cannabis could become a valuable tool for preserving vision and improving the quality of life for those at risk of or suffering from it.
Visit online dispensaries like GrassLife to explore strains that may help in managing this health issue.
Frequently Asked Questions
Can marijuana interact with other medications for AMD?
Yes, marijuana can interact with other medications. Here are the main points to consider:
- Blood Pressure Medications. Affects blood pressure. Blood pressure meds might cause unexpected changes.
- Blood Thinners. Influences blood clotting. If you’re on blood thinners like warfarin, this could increase bleeding risk.
- Sedatives. Enhances the effects of sedatives and sleep meds. Leads to more drowsiness.
Can My Optometrist Or Ophthalmologist Provide Guidance On Marijuana For Amd?
Yes, your optometrist or ophthalmologist can guide you on using marijuana.
- Provide information on how marijuana interacts with current treatments.
- Provide advice based on your specific health needs.
- Check your progress and adjust your treatment plan as needed.
- Refer you to a medical marijuana specialist if necessary.
How Quickly Can I Expect To See Results From Using Marijuana?
People respond differently, and the method of consumption affects how quickly you notice changes. Smoking or vaping usually provides faster effects, while edibles or tinctures may take longer but last longer.
You might feel relief from symptoms like eye pain or inflammation within minutes to hours if you use methods like smoking or vaping. Improvements in vision or reduced inflammation might become noticeable within a few days to weeks. Significant changes can take several weeks to months of consistent use.
Are There Any Other Lifestyle Changes That Can Complement Cannabis Use For Amd?
- Eat regularly a diet rich in leafy greens, fruits, and fish high in omega-3 fatty acids.
- Regular physical activity can help maintain overall eye health.
- If you smoke tobacco, quitting can help slow the progression of it.
- Schedule efficient check-ups with your eye doctor to monitor your condition.